Loyola University of Chicago researchers have developed a genetically modified protein with potential in reversing the effects of vitiligo in mice.
The group of researchers led by Dr. Caroline Le Poole described their findings in an article published in "Science Translational Medicine"
Previous studies performed by this group of researchers have shown that the HSP70i protein plays a vital role in the autoimmune response that causes vitiligo.
HSP70i is a heat shock protein consisting of 641 building blocks called amino acids. Le Poole and her colleagues genetically modified one of these amino-acids to create a mutant HSP70i. The mutant HSP70i protein supplants HSP70i proteins, reversing the autoimmune response in vitiligo.
When administered to mice, HSP70i protein caused them to develop vitiligo. Their fur turned the colouring of salt-and-pepper. When vaccinated with the mutant HSP70i, their fur turned black again. The same effect could be observed on human skin samples.
Concerning the future of this discovery for the treatment of vitiligo, their still is a long way to go: the researchers are seeking regulatory approval and funding for clinical trials in humans.
SOURCE:
Mutant HSP70 Reverses Autoimmune Depigmentation in Vitiligo. Sci. Transl. Med. 5, 174ra28 (2013). http://stm.sciencemag.org/content/5/174/174ra28
Comments
keep up the good work, when
keep up the good work, when will this treatment be available ?
probably after all of the
probably after all of the human trial procedures will be completed and even after that there is a long period of waiting for approval. The research for this protein dates back to the 90s
Yes, the protein dates back,
Yes, the protein dates back, but as I understand, this a new modified version which can reverse Vitiligo, this could actually be what millions of people have been waiting for, the results are indeed striking, lets hope a speedy approval process
I agree- I understood the
I agree- I understood the protein to be a modified form and it does seem to carry striking results! I hope this is what millions of people have been waiting for ( myself included) to have quality of life back again! Please a speedy approval process- how great that would be!
I am not much confidence in
I am not much confidence in genetically modified proteins because if this will not meet the required criteria may be it will respond in a different from to this. May be it will cause a virus to spread the air.for more details
How can a person volunteer to
How can a person volunteer to participate in the upcoming trials? Whom should one contact?
I would like to volunteer in
I would like to volunteer in the human study to help
find a cure for vitiligo. Who do I submit my information to? jenmhudak @gmail.com
hello,Iam a Chinese patient,I
hello,Iam a Chinese patient,I am committed to launch Chinese vitiligo patients to signature application on June 25, to become the world vitiligo day!Can you help me to launch American patient to sign ,because it need 500000 people.This is the url link,http://25june.org/en/.My email vitiligochina@163.com,thank you!
quiero ser voluntario para la
quiero ser voluntario para la prueba de este tratamiento mi correo electronico es raul4567@hotmail.com
je suis tellement contente
je suis tellement contente que ça avance ça fera pleins de gens heureux a travers le monde merci merci
yo tambien quiero ser
yo tambien quiero ser voluntaria parala prueba mi correo electronico es nerd05@hotmail.com
Millions of people are
Millions of people are waiting for this treatment and all of us we have millions of hopes. God bless you to find a treatment. I would like to be a volunteer in the researches of the new treatment. Please inform me when is possible. My email is : brokenup_withlove@hotmail.com
Thank you in advance
The truth is that I tried
The truth is that I tried everything to cure my vitiligo problem, creams, laser treatments, medicines. After spending six years with vitiligo in most areas of my body, I found this treatment: www.naturalvitiligotreatmentsystems.com , could not believe what was happening to me, the first 2 weeks I was noticing the change. After 2 months I was almost cured. today I am completely healed without surgery, or exercise, or lasers, just with this natural diet treatment.
hi bryan can u send me that
hi bryan can u send me that pdf file to my mail imtiazsk.sk@gmail.com plss
Dear plz inform when this
Dear plz inform when this treatment availabal lots of people waiting for hsp70i plz save us life.
I need HSP70i protein ,I
I need HSP70i protein ,I become ... ,Help me and others please .
Plz cure me and da millions
Plz cure me and da millions all over the world... I wanna b free from dis vitiligo.. Plz support me n my feelings.. Chiyennewood@gmail.com
Bonjours je voudrais essayé
Bonjours je voudrais essayé votre protein mutante HSP70i.
Hello i want try protein mutante HSP70i, pliz.
I can go in america. It's important for mi.
Bonjours je voudrais essayé
Bonjours je voudrais essayé votre protein mutante HSP70i.
Hello i want try protein mutante HSP70i, pliz.
I can go in america. It's important for mi.
My email : rodolfomichel660@gmail.com
Thank you.
From Canada I too suffer from
From Canada I too suffer from this horrific disease. I also would like to be a candidate for your trials.
doylekillick@gmail.com
plz i want to be part of this
plz i want to be part of this please let me and africa know when the HSP70i protein is available and how to get it ...thabojele@yahoo.com
How can I volunteer to
How can I volunteer to participate in the upcoming trials? Whom should I contact?
when this medicine will be
when this medicine will be available in india?
I'm ready for any experiment
I'm ready for any experiment
I would like additional
I would like additional information as it becomes available. Thank you. Gsilva15@yahoo.com
we are waiting Dr. Caroline
we are waiting Dr. Caroline Le Poole, when????, its like waiting for our last hope....
Its like two years,,,there
Its like two years,,,there are more than 2 million people in india with vitiligo and more millions around the world.....pls answer us..
kindly let me know when will
kindly let me know when will be available in usa or india 'i would like to try it
Please let me know when I can
Please let me know when I can try this. I ready for trial.
Please let us know the latest
Please let us know the latest on when this will be offered to medical world. This disease is aemotionally debilitating . Please give us an update
Please let us know the latest
Please let us know the latest on when this will be offered to medical world. This disease is aemotionally debilitating . Please give us an update
When will they planning to
When will they planning to start human trial ??
There is some info on grantom
There is some info on grantom.com
i am 73 years old, i am
i am 73 years old, i am affeçted by vitiligo in all body from over 60 years. For me is not anymore
Estetic problem. IS A LIFE PROBLEM, I NEED TO BE PROTECTED FROM THE SUN BY
GARMENTS EVERY TIME. I CAN'T STAY FREE UNDER SUN IN THE BEACH, BOAT,
DURING TENNIS PLAY, SKY, WALKING. FINALLY WITHOUt CONSIDERING HOW THE
PEOPLES LOOKS YOU AS A MONSTER. VERY HARD LIFE
I am from Mumbai India please
I am from Mumbai India please let me know research progress update of hsp70i on humanbeings & how much time it will take to complet trial reseach all the vitiligo suffering pupils are desperately waiting for it It is our final hope. I would like to be part of trial of hsp70i if in India. My email is spam.sonawane@gmail.com
Hello.
Hello.
I am ready to be a candidate to try protain, plz, ....
ciliii@inbox.lv
Hello, I am a vitiligo
Hello, I am a vitiligo patient. I have vitiligo since I was 3 years old. Toad its been 23 years since I have this.Can anyone please update on the advancements made in HSP70i, and are they ready to roll the cure out in the market yet. I can come to the US if required to .
sir, iam india nd this is my
sir, iam india nd this is my mail imtiazsk.sk@gmail.com iam ready for trail
Why isn't there any news
Why isn't there any news about the modified protein HSP70i??? This article is more than 3 years old! Someone must know something, right? Mail me R6velocita@gmail.com
Update for this treatment on:
Update for this treatment on:
http://grantome.com/grant/NIH/R44-AR065886-02A1
Add new comment